Synthetic approaches towards chiral leukotriene analogues

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Statementby Mark C. Rogers-Evans.
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Synthetic approaches towards chiral leukotriene analogues This item was submitted to Loughborough University's Institutional Repository by the/an author.

Additional Information: • A Doctoral Thesis. Submitted in partial ful lment of the requirements for the award of Doctor of Philosophy of Loughborough Universit.y. Synthetic approaches towards chiral leukotriene analogues A review of the discovery, biological activity and chemical synthesis of the leukotrienes is presented, together with the latest developments in their structural modification to produce useful : Mark C.

Rogers-Evans. Synthetic approaches towards chiral leukotriene analogues. (Thesis) ' ' Rogers-Evans MC Publisher: Loughborough University of Technology [] Metadata Source: The British Library Type: Thesis. Abstract. No abstract provided. Menu. Formats. Abstract. EThOS. About. About Europe PMC; Funders; Joining Europe PMC.

Synthetic approaches towards chiral leukotriene analogues Strategies are\ud presented for the preparation of chiral leukotriene derivatives in which\ud the characteristic triene unit is replaced by various aromatic groups and\ud include:\ud (i) The preparation and attempted separation of the racemic\ud diastereomers Synthetic approaches towards chiral leukotriene analogues book methyl S-hydroxy(2 Author: Mark C.

Rogers-Evans. This review summarizes synthetic strategies for the preparation of asymmetric phthalocyanines and their analogues. Cross-condensation between two phthalonitrile components, crosscondensation between one phthalonitrile and one non-nitrile component.

An interesting approach towards recycling these undesired isomers has been reported, using a base catalysed carbon-carbon bond cleavage reaction to regenerate 1 and 2. 33 Yields of 1 and 2 as high as 90% could be accomplished within 1 h at room temperature, using.

Carbohydrate starting materials continue to be the mainstay in synthetic endeavors toward various antifungal peptidyl nucleoside antibiotics. Some of the other natural peptidyl nucleosides, such as the ezomycins, amipurimycin, and miharamycins, also exhibit potent antifungal activity against a broad range of fungal by: 1.

Introduction. Advances in Organic Synthesis is a book series devoted to the latest advances in synthetic approaches towards challenging structures.

It presents comprehensive articles written by eminent authorities on different synthetic approaches to selected target molecules and new methods developed to achieve specific synthetic : Atta-ur-Rahman, Jan Spengler, Fernando Albericio, Frédéric Hapiot, Loïc Leclercq, Nathalie Azaroual.

Issue in Honor of Prof. (Mrs.) Asima Chatterjee ARKIVOC (ix) A synthetic approach to chiral carbocyclic nucleosides of varied. ring-sizes using carbon framework of D-glucose. Kaushik Singha, Basudeb Achari, and Sukhendu B.

Mandal*. Division of Medicinal Chemistry, Indian Institute of Chemical Biology, Jadavpur,Cited by: 1. Synthetic approaches towards chiral leukotriene analogues Author: Rogers-Evans, Mark : Mark C. Rogers-Evans. The medicinal chemistry of stable synthetic leukotriene B-3 and B-4 analogues Article Literature Review in Future medicinal chemistry 4(8) May with 6 Reads How we measure 'reads'.

Description Synthetic approaches towards chiral leukotriene analogues FB2

Quinolones are broad-spectrum synthetic antibacterial drugs first obtained during the synthesis of chloroquine.

Nalidixic acid, the prototype of quinolones, first became available for clinical consumption in and was used mainly for urinary tract infections caused by Escherichia coli and other pathogenic Gram-negative bacteria. Recently, significant work has been carried out to synthesize Cited by: A concise and high-yielding double aza-Michael reaction is presented as an atom-efficient method to access chiral 2-substituted 4-piperidone building blocks from divinyl ketones.

The piperidones were further converted into analogues of donepezil, an acetylcholinesterase inhibiting drug used in the treatment of Alzheimer’s disease. The donepezil analogues were obtained as inseparable Author: Anna Poeschl, David M. Mountford, Robert C.

Hider, Agostino Cilibrizzi. access from natural sources has stimulated many synthetic efforts towards huperzine A and resulted in a number of successful total syntheses of this alkaloid. The first of its kind produced the racemic material and were independently accomplished by Kozikowsky and Qian & JiCited by: 2.

Thieme E-Books & E-Journals. DE EN; Home Products. Journals Books A Novel Synthetic Approach towards Chiral QUINAP via Diastereomeric Sulfoxide Intermediates Synthesis of Mono- and Bis-C-glycosylated 2,3,4-Trisubstituted 1H-Pyrroles as Cyclo- and Acyclo-C-nucleoside Analogues.

Consideration of several approaches showed that the approach via the intermediate a (Scheme 5) was the most efficient and industrially feasible.

In this route, stereocontrol is effected by intramolecular alcoholysis of the enantio-oxazolinoazetidinone derivative 68 giving the 7- epi.

A series of tenofovir analogues with potential antiviral and immunobiologically active compounds were synthesized through an asymmetric transfer hydrogenation reaction from achiral purine derivatives.

Up to 97% ee and good to excellent yields were achieved under mild conditions through short reaction by: Thieme E-Books & E-Journals. DE EN; Home Products. Journals Books Versatile Synthetic Approaches Towards Aza-analogues of Illudin and Ptaquilosin Sesquiterpenes Diastereoselective Michael Reactions of Azomethine Ylides to Chiral 4-Methyleneoxazolidinones.

An overview of the synthesis and applications of chiral 2,3-epoxy alcohols containing unsaturated chains is presented. One of the fundamental synthetic routes to these compounds is Sharpless asymmetric epoxidation, which is reliable, highly chemoselective and enables easy prediction of the product enantioselectivity.

Thus, unsaturated epoxy alcohols are readily obtained by selective oxidation Cited by:   These chapters also describe chiral pool synthesis by means of carbohydrate precursors.

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This book also examines the methodologies in organic synthesis using reagents with boron, aluminum, transition metals, silicon, phosphorus, and sulfur. The remaining chapters are devoted to reactions involving radical initiated ring closure, Book Edition: 1.

A new class of molecules, WAu 12 (see picture) and its isoelectronic analogues, has been proposed and theoretically studied. The calculated radial W Au distance is unusually short, pm at the best level of theory.

The frontier orbitals, both HOMO and LUMO, have fivefold degenerate h g symmetry. The gap between them approaches 3 eV.

Advances in Organic Synthesis is a book series devoted to the latest advances in synthetic approaches towards challenging structures. It presents comprehensive articles written by eminent authorities on different synthetic approaches to selected target molecules and new methods developed to achieve specific synthetic : Atta-ur-Rahman, Jan Spengler, Fernando Albericio, Frédéric Hapiot, Loïc Leclercq, Nathalie Azaroual.

Details Synthetic approaches towards chiral leukotriene analogues FB2

2,5-Disubstituted tetrahydrofurans constitute the core skeleton of several natural products and are pivotal synthetic analogues of medicinal importance that exhibit remarkable bioactivities.

Oxasqualenoid natural products are implicated as potent biologically active molecules, particularly with regard to dem.

Prof. Hiroyuki's current research interest is focused on the development of new and efficient synthetic reactions, new reactive molecules, and new chemical principles that will exert impact on the future of chemical, biological and material sciences.

He has more than research publications, 61 review publications and 28 book chapters. Alkaloids are not only one of the most intensively studied classes of natural products, their wide spectrum of pharmacological activities also makes them indispensable drug ingredients in both traditional and modern medicine.

Among the methods for their production, biotechnological approaches are gaining imp. The synthesis of lignans and their analogues is an active field in the synthetic organic chemistry community.

Tremendous synthetic efforts on this family have been well documented by reviews [9,10,11,12,13,14,41,47,48,49,50,51].Cited by: 4. Analysis of the role of synthetic organic chemistry in the identification of chemical starting points for drug discovery and subsequent optimization into candidate drugs indicates that a small Cited by:   While much remains to be revealed about the biological properties of psymberin, pederin, mycalamides, and analogs, it is reasonable to conclude that the novel synthetic approaches discussed here and in recent reviews [71, 72] will evolve to yield more potent and more highly-targeted compounds in the near : Zbigniew J.

Witczak, Ajay Bommareddy, Adam L. VanWert. The -NH- group in a peptide bond can be replaced by alkylated -NR- or -O- groups. N-Alkyl peptides are important modifications which commonly occur in natural peptides.

The Nα -alkylation induces significant structural effects: the occurrence of the cis -isomer in the secondary amide bond, steric effects, Cited by: Book of abstracts 7ENQO Sociedade Portuguesa de Química 16thth July Lisboa, Portugal synthetic approaches towards (+)-alexine utilizing a novel [3+2]-annulation reaction 11h45 – 12h30 as many chiral auxiliaries and ligands contain this substructure.

Towards the ideal synthesis. The design of structurally simpler but functionally superior analogues — an approach which in turn can be mimicked by much simpler analogues Synthetic Cited by: An approach for synthesis of axially chiral Indolostilbenes via Ferric chloride oxidative cyclization.

Munirah Suhaimi, Mohamad Nurul Azmi, Kartini Ahmad, Mohd Azlan Nafiah, Ibrahim Noorbatcha, Noel F. Thomas and Khalijah Awang. 4th Penang International Conference for Young Chemist (ICYC ) (30th Jan-1st Feb ) Bayview Hotel, Geogtown.SYNTHETIC APPROACHES TO NOVEL, TRIAZOLE-CONTAINING OLIGONUCLEOTIDE ANALOGUES Lia Ashley Maria Tazioli Submitted for the degree of Doctor of Philosophy Heriot-Watt University, School of Engineering and Physical Sciences, September The copyright of this thesis is owned by the author.

Any quotation from this thesis orAuthor: Lia Ashley Maria Tazioli.